it's not going to "affect" anything marijuana affects person behavior to affect many older people. to affect many other people. to influence someone or something, or cause them to change It's a disease which affects many older people.
"the chairman's nephew has a lot of clout" He always boasts about his friends in high places, but actually he has no political clout. Jack has a real clout around here. Kaczyński's opinions carry a lot of clout.